This hypothesis has not yet been tested for S. aureus. Nonetheless, the possibility that redox defense is enhanced by LplA2-mediated lipoylation of GcvH-L could conceivably provide a partial explanation for the reduced virulence seen upon infection with a ΔlplA1ΔlplA2 double mutant in the sepsis model (Fig 6). Here, PLA2G15 is linked to Sepsis.