In contrast, levels of ΔlipAΔlplA1ΔlplA2+lplA1 and ΔlipAΔlplA1ΔlplA2+lplA2 in infected hearts were only partially restorative, in support of our previous findings that suggest de novo biosynthesis plays a dominant role in infection of the heart. This evidence concerns the gene PLA2G15 and infection.