PCDH1 and asthma: Nevertheless, it remains unknown how PCDH1 would interact with E-cadherin or other molecules of the epithelial adhesion complex to mediate its effect on epithelial barrier function, how reduced barrier function due to loss of PCDH1 would affect permissiveness of the epithelium to large molecules such as FITC-Dextran, and in what specific subgroup of asthma patients PCDH1 would show this effect.