In the global portfolio of malaria medicines, other recently discovered novel compounds are the synthetic peroxide OZ439 [18], the spiroindolone KAE609 [31], the imidazolopiperazines KAF156 [32], the dihydroorotate dehydrogenase inhibitor DSM265 [33], and the translation elongation factor 2 inhibitor DDD107498 [23]. This evidence concerns the gene DHODH and malaria.