MAPT and Alzheimer disease: Compelling evidence suggests that intracellular neurofibrillary tangles rather than neurotic plaques are more closely correlated with the cognitive decline and severity of AD.1, 2 In addition, concentrations of tau protein, detected in the cerebrospinal fluid of subjects at risk for AD, were increased 15 years before expected symptom onset.3 Given the evidence that the tau hyperphosphorylation is critical to induce neuronal death,4, 5 it has become widely recognized that tau-based therapeutic strategies may be not only effective for AD but also for other diseases with tauopathies.