We report several genes, most notably RGS2 (regulator of G-protein signaling 2) and DLGAP1 (disks, large (Drosophila) homolog-associated protein 1) with low expression correlated with higher Aβ sensitivity in LCLs from healthy individuals and lower expression in LCLs from AD patients, as well as in postmortem AD brain tissues and both AD and MCI peripheral blood. Here, RGS2 is linked to Alzheimer disease.