Last, RGS2 has been reported as the only RGS family member that inhibits the mRNA translation into protein of eIF2Bε (eukaryotic initiation factor 2B ε subunit),74 a protein crucial for correct protein folding, a process dysfunctional in neurodegenerative disorders including HD, AD and prion diseases, and mutations in which cause childhood ataxia.75 This novel role of RGS2 supports its postulated defensive mechanism in both HD and AD, whereby reduced RGS2 expression reflects an attempt to protect cells from misfolded protein accumulation by enhancing eIF2Bε translation.76 Here, PITX2 is linked to Huntington disease.