The expression levels of two additional genes, SIRT1 and SARM1, albeit not found in our genome-wide transcriptomic experiment, were also analyzed in the same AD and healthy control LCLs, as both have been implicated in AD,31, 32, 33, 34, 35 and SIRT1 expression was reduced in postmortem AD parietal cortex.36 The RNA samples were extracted and converted to cDNA for determining the expression levels of selected genes by real-time PCR (Supplementary Table 2). The gene discussed is SIRT1; the disease is Alzheimer disease.