RGS2 and Alzheimer disease: GPCRs are the largest gene family in the human genome (~800 members) and ~40% of current therapeutics are GPCR ligands.77 Our findings of the GPCR regulator RGS2 as deregulated in AD LCLs (Figure 3a), and that its expression was correlated with AD patients' MMSE and ADAS scores (Figures 4a and b), are intriguing.