Some genes were selected mainly because of their location in the 22q11.2 region (COMT, DGCR2, DGCR8 and UFD1L), as its deletion is one of the strongest known genetic risk factors for psychotic disorders.19 We previously analyzed the same genes in other studies comparing FEP (excluding individuals with bipolar disorder diagnosis) with ultra-high risk individuals and controls, with positive findings.11, 12, 20, 21, 22, 23 Here a comparison between FEP of schizophrenia spectrum disorder (SCZ) and FEP with mania (BD) is presented, as well as between BD and healthy controls. This evidence concerns the gene DGCR8 and Behcet disease.