The clinical characteristics and pathological findings of these two cases with ectopic ACTH production compared to other pheochromocytomas without ACTH production were quite evident with signs and symptoms of increased cortisol secretion, even though they did not both present with all classic signs such as hypokalemia, hyperglycemia (even though also pheochromocytomas can give hyperglycemia but normally not to the same degree), easy bruising, changes in fat distribution, and so on. This evidence concerns the gene POMC and Hypokalemia.