Since pre-operative petrosal sinus sampling/CRH assays and post-operative CRH immunostaining are not routinely performed when pheochromocytoma-associated ACTH-dependent Cushing’s syndrome is suspected, some published cases could have been misclassified as ACTH-secreting instead of CRH-secreting. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.