TBX22 and ankyloglossia: Due to its essential role in human palatogenesis, mutations in one of the TGF members, TBX22, have been reported in patients with OFCs and TA as well as in OFC-associated syndromes, such as inherited X-linked cleft palate with ankyloglossia (OMIM# 303400) and in Abruzzo–Erickson syndrome (OMIM# 302905) (Braybrook et al. 2001, 2002; Herr et al. 2003; Marçano et al. 2004; Suphapeetiporn et al. 2007; Kim et al. 2009; Pauws et al. 2009, 2013; Acevedo et al. 2010; Kantaputra et al. 2011; Kaewkhampa et al. 2012; Gurramkonda et al. 2015).