Another locus associated with a known cleft syndrome, DiGeorge syndrome (OMIM# 188400), is located on chromosome 22 containing the main causative gene, TBX1. In four young patients with DiGeorge syndrome, the deletion of the locus 22q11 was diagnosed along with a CP and TA (Table 4; Supplementary Table 6) (Heliövaara et al. 2011). The gene discussed is TBX1; the disease is 22q11.2 deletion syndrome.