Mutations in FGFR1 are also described as causative for other syndromes, some of them including OFCs and dental anomalies (Kim et al. 2005; Riley et al. 2007; Stoler et al. 2009; Simonis et al. 2013), like a gain-of-function FGFR1 mutation associated with Kallmann syndrome and loss-of-function mutations in craniosynostosis presenting OFCs (Dodé et al. 2003). The gene discussed is FGFR1; the disease is Kallmann syndrome.