MSX1 and Wolf-Hirschhorn syndrome: Even though MSX1 mutations are known to cause non-syndromic OFCs and TA, Nieminen et al. (2003) described the case of a patient with Wolf–Hirschhorn syndrome (WHS) (OMIM# 194190) due to a complete deletion of the MSX1 gene (Table 2; Supplementary Table 4), which is located in the deleted region in chromosome 4p, whose craniofacial features included CP as well as TA (Paradowska-Stolarz 2014).