TP63 and Down syndrome: Mutations in the TP63 gene itself have been associated with multiple syndromes, called p63 syndromes: ectrodactyly-ectodermal dysplasia-clefting (EEC) (OMIM# 129900), split-hand/foot malformation type 4 (SHFM4) (OMIM# 605289), ankyloblepharon-ectodermal dysplasia-cleft syndrome (AEC) (OMIM# 106260), acro-dermato-ungual-lacrimal-tooth syndrome (ADULT) (OMIM# 103285), limb-mammary syndrome (LMS) (OMIM# 603543) and Rapp–Hodgkin syndrome (RHS) (OMIM# 129400).