NECTIN1 and cleft lip/palate-ectodermal dysplasia syndrome: Mutations in PVRL1, encoding an adhesion protein contributing to the adherent and tight junction formation in epithelial and endothelial cells, are known to cause CL/P-ectodermal dysplasia syndrome (CLPED, a.k.a. Zlotogora syndrome) (OMIM# 225060) as well as non-syndromic CL/P (EntrezGene; Suzuki et al. 2000; Sözen et al. 2001; Turhani et al. 2005; Avila et al. 2006; Scapoli et al. 2006; Sözen et al. 2009).