WNT3 and Amelia: Mutations in WNT3 are well-known causes of syndromic tetra-amelia with CLP (OMIM# 273395), but the disruption of this gene has recently also been described as involved in non-syndromic OFC with TA (Table 2; Supplementary Table 4) (Yao et al. 2011; Mostowska et al. 2012).