SATB2 and ankyloglossia: In a large number of studies, the contribution of SATB2 variants to OFCs in human has been confirmed, especially CP, both in non-syndromic OFC (OMIM# 119530) as well as in syndromes such as Glass syndrome (OMIM# 612313), and Pierre Robin sequence with or without ankyloglossia and cleft-associated intellectual disability (OMIM# 261800) (FitzPatrick et al. 2003; Beaty et al. 2006; Britanova et al. 2006; Leoyklang et al. 2007; Rosenfeld et al. 2009; Urquhart et al. 2009; Rainger et al. 2014).