These T-cells reportedly recognize Qa-1b in a TCR dependent manner and act to suppress autoreactive CD4+ T-cells, thereby attenuating the development of autoimmune encephalomyelitis (a mouse model of multiple sclerosis), very similar to the role of HLA-E restricted CD8+ T-cells evoked by vaccination in human MS [67–69]. This evidence concerns the gene HLA-E and multiple sclerosis.