TNF and obstructive sleep apnea syndrome: It has been reported that the release of tumor necrosis factor-alpha and interleukin-8 production from peripheral blood in patients suspected OSA was not different compared to non-OSA subjects and in patients showing similar prevalence of major cardiovascular risk factors and cardio-metabolic therapies, differing for the presence or absence of OSA, cytokine productions from peripheral blood were similar [27].