PTH and Hypercalciuria: In an experiment performed by Zhang et al., the water fraction of Fructus Ligustri Lucidi (FLL) ethanol extract (WF-EE, 574 mg/kg, i.g.)has been demonstrated to improve the trabecular bone deteriorations and inhibit hypercalciuria and increase serum parathyroid hormone (PTH) and fibroblast growth factor-23 in streptozotocin (STZ, 40 mg/kg) induced DBA/2J mice [25].