Phenotypes caused by the genes endothelin 3 (END3), endothelin receptor B (EDNRB), microphthalmia-associated transcription factor (MITF), paired box 3(PAX3), SRY-box 10 (SOX10), and snail homolog 2 (SNAI2) can result in decreased melanocytes, white coat color, and ultimately deafness. The gene discussed is EDNRB; the disease is deafness.