CD4 and Autoimmunity: The observed “reprograming” of antigen-specific naive and memory CD4+ T cells by MPLA-tDCs to a stable hyproresponsive state is in accordance with a study of Woltman and colleagues (29) and suggests that in the context of autoimmunity, transferred autologous MPLA-tDCs would be able to silence autoreactive T cell responses, either at their initiation, preventing the differentiation of autoantigen-specific naive CD4+ T cells toward proinflammatory Th1 or Th17 cells, or by turning off already developed effector T cell responses.