NELFCD and parasitic infectious disease: Recently, it was reported that Lgals1−/− mice infected intradermally with T. cruzi are resistant to this parasitic infection compared to their WT counterparts and this resistant phenotype could be associated with a dysfunction in the regulatory properties of Gal-1 followed by high production of Th1 proinflammatory cytokines and improvement of Th1 and CD8+ T cells responses [25].