Then, considering that (i) immunoregulatory properties of Gal-1 are associated with regulation of TH 1 and TH 17 responses [59], (ii) IL-12 and IL-23 share p40 subunit [60], and (iii) IL-17/IL-23-axis cytokines participate in immune response against H. capsulatum infection [33], further investigation should be done in order to elucidate the impact of IL17/IL23 in experimental histoplasmosis in the absence of endogenous Gal-1. The gene discussed is IL17A; the disease is histoplasmosis.