Although the expression of Gal-3 in dendritic cells is not upregulated in WT mice infected with H. capsulatum, mice genetically deficient in Gal-3 clear this fungal infection more efficiently than WT mice [13], showing that high Gal-3 expression in WT mice is not required for the participation in the immune response against H. capsulatum and may actually contribute to pathogenesis [13]. The gene discussed is LGALS3; the disease is fungal infectious disease.