To define molecular mechanisms underlying skin pathologies seen in K14-Angptl6 Tg mice, we undertook gene-expression profiling of whole ear tissue from 20-week-old K14-Angptl6 Tg versus comparably aged wild-type littermates using RNA sequencing technology (Fig. 2a, Tables 1 and 2). The gene discussed is KRT14; the disease is neoplasm.