By contrast, S100A8 and S100A9 proteins were abundant in skin tissues of all 15 psoriasis patients but not in tissues from any non-psoriasis control subject (Fig. 4, Supplementary Fig. S5, Tables 3 and 4), suggesting that ANGPTL6 production and S100A8/S100A9 expression are not linked in the pathogenesis of psoriasis. This evidence concerns the gene ANGPTL6 and psoriasis.