Therefore, we asked whether S100A9 loss would alter psoriasis-like skin phenotypes in K14-Angptl6 Tg mice by genetically deleting S100a9 in K14-Angptl6 Tg mice (K14-Angptl6 Tg;S100a9−/−) using CRISPR-Cas9-mediated technology (Supplementary Fig. S2). This evidence concerns the gene ANGPTL6 and psoriasis.