ANGPTL6 and psoriasis: In this study, we found that ANGPTL6 overexpression in keratinocytes of transgenic (K14-Angptl6 Tg) mice promotes thickened epidermis marked by hyper-proliferation of prematurely differentiated keratinocytes and increased chemokine/cytokine expression, accelerating recruitment of neutrophils and endothelial cells to epidermis and contributing to phenotypic changes associated with psoriasis.