Conversely in EGFR expressing tumours HNC (CAL-27, SCC-61, SCC-35 and SQ-9G), NSCLC (A549) and colorectal (HCT-116), tumour xenografts showed Cy5 signal accumulation for up to 72 h after C-MMAE injection while tumours from low EGFR LN-229 did not (Fig. 4c, Supplementary Fig. 9). The gene discussed is EGFR; the disease is neoplasm.