These results are in line with published data on RAS mutant paediatric B-ALL samples (not MLL rearranged) that were treated with two different MAP2K1/MAPK1 inhibitors (i.e. PD98059 and U0126) showing higher cytotoxicity in the mutant samples and no effects in the RASwt specimens50. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.