JAG1 and intrahepatic cholangiocarcinoma: In this study, we found that, in the mouse TAA model of ICC, Kupffer cells are immediately, but transiently, assembled to the pericentral zone of the hepatic lobule and express Jagged-1 in response to the TAA-induced hepatic injury, which leads to Notch signal activation in pericentral hepatocytes and their subsequent conversion into biliary lineage cells that become a source of ICC (Fig. 6).