Previous studies have demonstrated that Rxra, Pparg, Nrf1, and Srf were associated with atherosclerosis through lipid metabolism or transportation14, 29, 30; vascular smooth muscle cell proliferation31; inflammation32, 33; Esr1 and Runx3 were related to the risk of atherosclerosis15, 17. The gene discussed is RUNX3; the disease is atherosclerosis.