GBM patients with higher levels of TCF4, lower levels of FZD6 or TCF4 high/FZD6 low had a longer overall survival, whereas GBM patients with lower TCF4 expression or higher FZD6 expression had worse prognosis (Fig. 8c,d; Supplementary Fig. 13d). The gene discussed is TCF4; the disease is glioblastoma.