Supporting our proposal of KV1.3 inhibitors for reducing detrimental microglia functions are findings from our own group that PAP‐1 reduces infarct areas and improves neurological deficit in ischemic stroke in rats (Chen et al., 2013) as well as a report from Peng et al. that ShK‐170 (a close derivative of ShK‐186) protects mice from microglia mediated radiation‐induced brain injury (Peng et al., 2014). The gene discussed is KCNA3; the disease is ischemic stroke.