Given that TGF-β induces a cross-talk of signaling to the Smad1/5/8 pathway in cancer and endothelial cells (Liu et al., 1998; Goumans et al., 2002), it is possible that BMP7 coupling to the Smad3 signaling pathway is involved in regulating gene expression program beyond that of the hTERT directly or indirectly via a gene transcription-dependent mechanism. The gene discussed is SMAD1; the disease is cancer.