It is interesting to note that, for the high-PRL group, levels of FSH and LH were decreased and levels of oestrogen also showed a significant decrease, supporting the hypothesis that high-PRL levels inhibit the hypothalamic-pituitary-gonadal axis and thus that antipsychotic medication may play a role in the development of osteoporosis in patients with schizophrenia. The gene discussed is PLOD1; the disease is osteoporosis.