Around 2 % (2/91) of our patients had CHEK2 variants, V:87 had both c.190G > A, p.Glu64Lys and c.470T > C, p.Ile157Thr and I:20 had the splice variant c.319 + 2T > A, and they did present with polyps or CRC but no breast cancer has been reported in the families as we know of. Here, CHEK2 is linked to breast carcinoma.