CHEK2 and breast carcinoma: In a recent multigene-panel based CRC study 1.4 % (8/586) had CHEK2 risk alleles or truncating mutations, two of the patients had the c.470T > C, p.Ile157Thr, variant and four c.1100delC alleles, all had polyps or CRC, none of them had a personal history of breast cancer, but six had at least one family member with breast cancer [6].