MBNL1 and myotonic dystrophy type 1: Indeed, this idea may be reflected in the evidence that although Mbnl1 overexpression, in the widely used DM1 mouse model the HSALR mouse, was reported to rescue myotonia and several key splicing events known to be misspliced in DM1, other features of the phenotype were not restored, such as normal myofiber structure.51