The results of our RT-PCR screen revealed that the overexpression of Stau1 in DM1 resulted in both beneficial splicing events (25 ASEs), such as the rescue of the INSR exon 11, and detrimental splicing effects (8 ASEs), which could exacerbate the DM1 pathology, for example, the splicing of hnRNP A2B1. Here, HNRNPA2B1 is linked to myotonic dystrophy type 1.