Several of the Stau1-regulated mRNAs we identified also harbour splicing events shown to be misspliced in the hippocampus of adult DM1 mouse models, for example, KCNMA1 and CACNA1d. 55Our recent work shows that Stau1 acts as a splicing regulator in several different cell types, thus, one could speculate that indeed a misregulation of Stau1 in various tissues types, in addition to muscle, would result in splicing changes within these tissues. Here, KCNMA1 is linked to myotonic dystrophy type 1.