F8 and hemophilia A: Some other approaches have also been proposed to induce tolerance to factor VIII (FVIII) in hemophilia A, i.e., administration of B cell blasts transduced by FVIII-immunodominant domains using a retrovirus-mediated gene transfer (14) or intraosseous infusion of LV encoding FVIII under the control of platelet-specific promoters (15).