The effects of various NF-κB knockout combinations have been reviewed extensively and will not be further elaborated here, but it is important to note that the concept of NF-κB inhibition is complex and a greater understanding of the role of each subunit and component of the NF-κB pathway is required in order to develop appropriate targets for inhibition without impairing cellular immunity and responses to infections (Gerondakis et al., 2006). This evidence concerns the gene NFKB1 and infection.