First, an ACTH-sensitive MGC transduction system exists in rat adrenocortical carcinoma 494 cells and in isolated adrenal fasciculata cells (Perchellet and Sharma, 1980; Shanker and Sharma, 1980; Jaiswal and Sharma, 1986; Jaiswal et al., 1986; Venkataraman et al., 1998; reviewed in Sharma, 2010). The gene discussed is POMC; the disease is adrenal cortex carcinoma.