Purification and characterization of an MGC from rat adrenocortical carcinoma (Paul, 1986; Paul et al., 1987; Sharma, 1988; Sharma and Duda, 2014b) and subsequently from adrenal cortex (Takayanagi et al., 1987; Meloche et al., 1988) brought the discovery that it is a receptor for atrial natriuretic factor (ANF). The gene discussed is NPPA; the disease is adrenal cortex carcinoma.