CNR1 and Alzheimer disease: Given the vascular alterations observed in AD and in its animal models, and that cannabinoid agonists show vascular effects, in this work we sought to investigate the vascular responses of two pharmacologically distinct cannabinoid agonists, the CB1/CB2 mixed agonist WIN 55,212-2 (WIN) and the CB2 selective agonist JWH-133 (JWH).