Our analysis of the proliferation and invasion characteristics of RCC cancer cell lines following both si-RNA knock down of endogenously re-expressed CRHBP after 5-aza-2 ́-deoxycytidine treatment as well as ectopic re-expression of CRHBP in an epigenetically silenced RCC cell line interestingly revealed substantial alteration in the matri-gel invasion assay. Here, CRHBP is linked to renal cell carcinoma.