In view of our previous finding describing substantially reduced mRNA expression in renal tumors [7] we asked whether low mRNA expression of CRHBP in renal cancer cell lines showing a high degree of CRHBP CGI methylation increases due to treatment of cells with the DNA methyltransferase inhibitor 5-aza-2 ́-deoxycytidine. This evidence concerns the gene CRHBP and renal carcinoma.