Infection with PLKO.1TrkC.T1 reduced TrkC.T1 mRNA (Fig 3C) and protein (Fig 3D) without affecting TrkC-FL mRNA or protein, and control virus PLKO.1Scrambled had no effect on expression of either TrkC.T1 or TrkC-FL mRNA and protein. The gene discussed is NTRK3; the disease is infection.