Given the known role of TNF-α in human ALS [10], our data showing the role of TrkC.T1 at increasing neurotoxic TNF-α, and the correlation of TrkC.T1 up-regulation associated with down-regulation of miR-128 and disease progression in human sporadic ALS and in an ALS animal model, we suggest that TrkC.T1 may be a potential target for ALS therapy. Here, TNF is linked to amyotrophic lateral sclerosis.