As shown in Fig. 4, when the expression profiles of TG and syndecans were superimposed with parameters of renal scarring progression (peri-glomerular and tubular) and renal insufficiency (proteinuria and serum creatinine) of the rat kidneys post-SNx35, the expression of Tgm2 and Sdc4 were predominant, paralleled disease development (Fig. 4A) and significantly correlated in the SNx model (Fig. 4B). This evidence concerns the gene SDC4 and Renal insufficiency.