SDC1 and Renal insufficiency: As shown in Fig. 4, when the expression profiles of TG and syndecans were superimposed with parameters of renal scarring progression (peri-glomerular and tubular) and renal insufficiency (proteinuria and serum creatinine) of the rat kidneys post-SNx35, the expression of Tgm2 and Sdc4 were predominant, paralleled disease development (Fig. 4A) and significantly correlated in the SNx model (Fig. 4B).