rs3731249, encoding CDKN2A p.Ala148Thr, has been shown to reduce tumor suppressor function of p16INK4A, increase susceptibility to leukemic transformation of hematopoietic progenitor cells and to be preferentially retained in ALL cells.49 The more common variant rs662463 correlated with rs77728904 has concurrently been suggested as a plausible causative variant underlying this new association signal48 (MAF=0.07, r2=0.16, D′=1.00 with rs3731249). This evidence concerns the gene CDKN2A and acute lymphoblastic leukemia.