Thus, our findings highlight the notion that the relative levels of both proteins could be important in the pathogenesis of murine breast tumors and, by inference, potentially for the development of triple-negative breast cancers in humans, a subtype with a particularly poor prognosis.59 Further, other contrasts and parallels between this model and human disease can provide important insights into the factors driving human mammary tumorigenesis through the loss of the APC proteins. This evidence concerns the gene APC and triple-negative breast carcinoma.