KDM3A and ovarian carcinoma: Indeed, both OVCAR-5/CDDP and A2780/CDDP cells expressing KDM3A shRNAs showed high abundance of senescence-associated β-galactosidase positive cells as compared with scrambled control cells (Figures 3a and d), indicating that KDM3A prevents the cellular senescence to promote sustained growth of ovarian cancer.