Indeed, both OVCAR-5/CDDP and A2780/CDDP cells expressing KDM3A shRNAs showed high abundance of senescence-associated β-galactosidase positive cells as compared with scrambled control cells (Figures 3a and d), indicating that KDM3A prevents the cellular senescence to promote sustained growth of ovarian cancer. This evidence concerns the gene KDM3A and ovarian cancer.