H2BC12L and breast carcinoma: The dual mechanisms we reported here are in consistent with the recent findings on breast cancer, where KDM3A induced pro-invasive genes and repressed pro-apoptotic genes by demethylating histone (H3K9me2) and non-histone protein p53, respectively.23 Even though KDM3A is mechanistically engaged in similar pathways, the target genes and cellular functions controlled by KDM3A vary between breast and ovarian cancer.