Emerging evidences suggested that KDM3A is a hypoxic target gene and mediates the hypoxia-inducible factor-1α-induced tumor progression through epigenetic mechanisms.16 Since it is well established that hypoxic tumor microenvironment drives the aggressiveness and chemoresistance in ovarian cancer,17, 18 we focused our further studies on KDM3A. The gene discussed is KDM3A; the disease is ovarian cancer.