CSNK1A1 and renal cell carcinoma: This is the first time to show the clinical significance, especially the prognostic value of CK1α in RCC although altered CK1 isoforms expression have been reported to contribute to tumorigenesis and metastatic behavior in varieties of tumors.15, 16, 17, 18 Our data suggest that HPIP and CK1α may be potential targets for RCC therapy.