Although in some other types of cancer, such as colorectal carcinoma, lymphomas and breast carcinomas,28 CK1α acts as a tumor suppressor which is evidenced by the fact that loss of heterozygosity of CK1α gene causes a highly invasive carcinoma and reduced CK1α expression was often observed in those tumors.29 This evidence concerns the gene CSNK1A1 and invasive carcinoma.