DUOX1 and thyroid gland carcinoma: Also, our findings appear to contrast with recent findings indicating a role for DUOX1-derived H2O2 as a cause of oxidative DNA damage and genomic instability in response to ionizing radiation of the thyroid, as a potential mechanism of development of thyroid cancer.13 However, it is plausible initiation of lung carcinogenesis by oxidative events related to DUOX1 may be followed by subsequent epigenetic DUOX1 silencing in established tumors, which in turn may serve to promote invasiveness or metastatic potential.