DUOX1 and neoplasm: Our findings may be highly relevant for lung cancer, as the process of EMT is a critical determinant of tumor invasiveness and metastatic potential, and has been frequently linked with poor prognosis.29, 33 Furthermore, associations of DUOX1 silencing with increased CSC properties and resistance to EGFR inhibitors have important implications for anticancer therapies and suggest that development of approaches aimed at preventing or reversing DUOX1 silencing may be clinically useful in targeting invasive or metastatic lung cancer.