The process of EMT has been associated with acquired resistance of lung cancers to chemotherapeutic drugs and to TKI of the EGFR.38, 39 Because of the close relationship between DUOX1 and EGFR-dependent signaling,7, 8 we explored the association between DUOX1 silencing, EMT and sensitivity to the EGFR TKI erlotinib. This evidence concerns the gene DUOX1 and lung cancer.