In addition to silencing of DUOX1, lung cancers were also found to display silencing of DUOXA1,18 a maturation factor for DUOX1, which aids in its trafficking to the plasma membrane to function as a competent NADPH oxidase.2 Indeed, our findings indicate that RNAi-dependent silencing of DUOX1 also leads to suppression of DUOXA1 (Supplementary Figure S3A), which might contribute to observed EMT phenomena (for example, Figure 3). Here, FMO5 is linked to lung cancer.