DUOX1 and lung carcinoma: Also, while normal H292 cells showed impaired growth in the presence of erlotinib, both H292-E90 and H292-shDUOX1 cells displayed marked resistance to erlotinib up to 10 μM (Figure 2d), indicating that DUOX1 suppression may be an important determinant of acquired erlotinib resistance in lung cancers.