DUOX1 and lung carcinoma: In addition to silencing of DUOX1, lung cancers were also found to display silencing of DUOXA1,18 a maturation factor for DUOX1, which aids in its trafficking to the plasma membrane to function as a competent NADPH oxidase.2 Indeed, our findings indicate that RNAi-dependent silencing of DUOX1 also leads to suppression of DUOXA1 (Supplementary Figure S3A), which might contribute to observed EMT phenomena (for example, Figure 3).