NSD3 and breast cancer: While TLK2 is often co-amplified with RPSKB1 due to their vicinity (Supplementary Fig. 2), it is not uncommon that multiple closely located oncogenes are targeted by the same genomic amplifications in breast cancers, such as the co-amplifications of ERBB2 and GRB7 (ref. 42), FGFR1 and WHSC1L1 (ref. 43), or PAK1 and GAB2 (ref. 44).