SIRT1 plays an important role in the development and progression of heart failure through the regulation of cell death/survival-related signalling [32, 33] and numerous evidence shows that molecules that activate SIRT1 are cardioprotective in several models of cardiovascular diseases, including DOXO-induced cardiotoxicity [24, 26, 34, 35]. This evidence concerns the gene SIRT1 and cardiovascular disorder.