The value of such lines lies in characterising the biology of genes that are frequently mutated in OSCC, including NOTCH1, CASP8 (Caspase 8) and FAT1 (an atypical cadherin) [6], which are not conventional oncogenes/tumour suppressor genes and can potentially have pleiotropic effects on tumour properties. The gene discussed is NOTCH1; the disease is neoplasm.