It was logical to speculate that OXGR1 acted as a suppressor of cardiac hypertrophy and results from the in vitro studies using an adenoviral-mediated OXGR1 overexpression system supported this notion; however, it is also important to know whether OXGR1 regulates the maladaptive or the adaptive hypertrophic pathways. The gene discussed is OXGR1; the disease is cardiac hypertrophy.