PPARG and neoplasm: Consistent with the reports that PPARγ agonists inhibit angiogenesis (Goetze et al., 2002; Keshamouni et al., 2005; Scoditti et al., 2010), we found that the number of blood vessels in tumor sections was increased in Tie2-g-KO mice but unaltered in Lyz-g-KO mice (Figure 1—figure supplement 1E–F), further indicating that PPARγ deficiency in macrophage alone is sufficient to augment tumor growth independent of changes in angiogenesis.