We conclude that the neutrophil chemotactic response towards fMLP is as co-ordinated in neonates as in adults, whereas the response to IL-8 is lower in neonates, indicating that neutrophils from newborn infants have a differential response to end-target and intermediate chemoattractants, which could lead to a reduced response to infections in newborn infants. The gene discussed is FPR1; the disease is infection.