In a study of 282 Japanese patients with transitional cell carcinoma and 257 healthy controls, it was determined that the combination of UGT2B7*1/*2 or *2/*2 with N-acetyltransferase 2 (NAT2) genotypes showed the highest risk for bladder cancer (OR = 4.2) after being adjusted for age and gender in these patients [22]. This evidence concerns the gene NAT2 and transitional cell carcinoma.