DNMT3A and neoplasm: To further validate data obtained by global methods on Dnmt3aΔ/Δ PTCL and to assess if methylation patterns are conserved in Dnmt3a+/- PTCL, we performed locus-specific methylation analysis using Combined Bisulfite Restriction Analysis (COBRA) for 11 selected genes in multiple independent tumor samples from Dnmt3aΔ/Δ and Dnmt3a+/- mice.