Similarly, we did not find any mutations in the coding sequences of two genes that are commonly mutated in human T cell malignancies, Tet2 and RhoA, and their expression was not changed in Dnmt3a-deffcient lymphomas, suggesting that changes in the activity of these genes may not be involved in the transformation of T cells in this model (S2 File and S2 Fig). The gene discussed is DNMT3A; the disease is lymphoma.