To determine whether the methylation landscape generated by WGBS is specific to the PTCL sample profiled or rather represents common changes that occur in Dnmt3a-deficient lymphoma, we validated hypo- and hypermethylated promoters using reduced representation bisulfite sequencing (RRBS) on additional normal CD8+ T cells and Dnmt3aΔ/Δ T cell lymphomas. Here, DNMT3A is linked to T-cell non-Hodgkin lymphoma.