Consistent with downregulation of p53 protein levels, GSEA revealed suppression of p53 pathway genes in both Dnmt3a+/- and Dnmt3aΔ/Δ PTCL tumors, such as GADD45a, ZFP36L1, and KLF4. Here, DNMT3A is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.