Studies using Gadd45a-/- mice found that ablation of Gadd45a in lymphoma-prone AKR mice decreased the latency and increased the incidence of T cell lymphomas, while deletion of Gadd45a on a p53 deficient background altered the tumor spectrum to heavily favor the development of T cell lymphomas [31]. Here, TP53 is linked to T-cell non-Hodgkin lymphoma.