KCNE1 and familial long QT syndrome: We selected eight mutations of residues mutated in patients with LQTS located in different segments of the KV7.1+KCNE1 channel and that were previously shown to form active channels (Bianchi et al., 2000; Yamaguchi et al., 2003; Eldstrom et al., 2010; Henrion et al., 2009; Yang et al., 2013; Yang et al., 2002; Harmer et al., 2010; Splawski et al., 1997).