We first study the biophysical properties of six point mutations in KV7.1 (F193L, V215M, S225L, L251P, F351S, R583C), and two in KCNE1 (K70N, S74L) identified in patients with LQTS (Yamaguchi et al., 2003; Yang et al., 2002; Splawski et al., 1997; Priori et al., 1999; Napolitano et al., 2005; Lai et al., 2005) (Figure 1a). The gene discussed is KCNE1; the disease is familial long QT syndrome.