First, three members of the deoxynucleotide triphosphate (dNTP) biosynthetic pathway were depleted during HIV infection: thymidylate synthetase (TYMS), which catalyses the methylation of deoxyuridylate (dUMP) to deoxythymidylate (dTMP); and two subunits of ribonucleotide reductase (RNR), RRM1 and RRM2, which catalyses the formation of deoxyribonucleotides from ribonucleotides (Figure 3B, left panels). The gene discussed is RRM2; the disease is HIV infectious disease.