BMI1 and melanoma: It is downregulated in melanoma tissues, which is associated with the poor prognosis of melanoma patients [24], and loss of miR-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression [8], Moreover, miR-203 also has inhibitory effects on the proliferation, migration, and invasion of melanoma cells via targeting versican and BMI1 [7, 25].