TP53 and carcinoma: Further examinations revealed that AOM-treated p53+/+; Sam68−/− mice had a statistically significant increase in the number of adenomas (12.67 ± 1.45 versus 5.5 ± 0.5) and carcinomas (8.67 ± 0.33 versus 6.5 ± 0.5) compared to p53+/+;Sam68+/+ mice (Figure 2).