Impaired synaptic transmission in DISC1 mutation carriers. Defect in depolarization induced vesicle release.1–2 weeks post‐conversion DISC1 carriers display larger soma and dentritic length.A large number of genes is differentially expressed at 4 weeks. Those are linked to synaptic transmission, dentritic spines and CNS development. 89 genes linked to mental Disorders. Here, DISC1 is linked to psychiatric disorder.